A Study of Urinary Endogenous Gamma-Hydroxybutyrate (GHB) Levels

Gamma-Hydroxybutyrate (GHB) Withdrawal

Gamma-Hydroxybutyrate (GHB) With-Drawal

Case A 35-year-old man with no significant medical history presented to a university ED complaining of anxiety. tremors and insomnia. The patient denied use of common street drugs or tobacco. He admitted to social weekend alcohol consumption, but had not been drinking during the preceding 2 weeks. His vital signs were: temperature 37.2OC, pi~lse 105/min. respirations 161 min. blood pressure 148...

Microchemical identification of gamma-hydroxybutyrate (GHB)

A new microcrystal test for the detection of gamma-hydroxybutyrate (GHB) is described. The silver/copper reagent consists of an aqueous solution of 0.1 g of cupric nitrate and 0.1 g of silver nitrate in 10.0 mL water. While some crystals form upon evaporation of the reagent, the test forms distinctive crystals for GHB and does not form crystals with some commonly encountered controlled substanc...

Gamma-hydroxybutyrate (GHB)-deficiency in alcohol-dependence?

I wish to propose a hypothesis that could help explain some of the effects of baclofen in alcohol dependence that are described in Dr. Bucknam’s case study (Bucknam, 2007) and in my self-case report (Ameisen, 2005). At a behavioural level, alcohol, baclofen and GHB all share sedative/hypnotic effects in humans. Clinical trials have shown baclofen to reduce anxiety in alcoholic (Krupitsky et al ...

Cloning and characterization of a rat brain receptor that binds the endogenous neuromodulator gamma-hydroxybutyrate (GHB).

Gamma-hydroxybutyrate (GHB) is an endogenous neuromodulator with therapeutical applications in anesthesia, sleep disorders, and drug addiction. We report the cloning of a GHB receptor from a rat hippocampal cDNA library. This receptor has a molecular mass of 56 kDa and belongs to the seven-transmembrane receptor family. The peptidic sequence has no significant homology with any known receptor, ...